One- and two-dimensional solid-state magic angle spinning NMR studies on the hydration process of layered sodium disilicate SKS-6

Three different kinds of silanols, which include isolated silanol, silanol I (with the hydroxyl proton bonded to an oxygen atom in the adjacent layer) and silanol II (with the hydroxyl proton bonded to the non-bridging oxygen at the same silicon atom), are generated during the hydration process of SKS-6 (δ-Na₂Si₂O₅). ¹H–¹H nuclear Overhauser enhancement spectroscopy reveals that the proton of silanol I has an effective chemical exchange or spin diffusion with the proton of hydrogen-bonded water, while the proton of silanol II is likely far away from the other proton-containing species. ²⁹Si magic angle spinning, ¹H→²⁹Si CP/MAS NMR and ¹H–²⁹Si phase-modulated Lee–Goldburg decoupled correlation experiments demonstrate that the local environments of the silicon sites in the final hydrated sample are mainly composed of Q² [(SiO)₂Si(OH)O⁻Na⁺], Q³ [(SiO)₃Si(OH) and (SiO)₃SiO⁻Na⁺] and Q⁴ [Si(OSi)₄] groups.     

基于苯并[b]萘并[1,2-d]噻吩的可见光驱动光环化荧光turn-on型二芳基乙烯的合成与性能研究

可见光驱动光环化的荧光turn-on型二芳基乙烯分子开关是超分辨显微成像的理想材料, 但目前关于该类型分子的报道仍较少. 本工作合成了一种基于苯并[b]萘并[1,2-d]噻吩(BNTP)的405 nm可见光驱动光环化的荧光turn-on型二芳基乙烯分子BNTP-BTTO4, 同时系统研究了该分子的光物理性能与稳定性, 并借助密度泛函理论(DFT)计算厘清了分子实现可见光驱动光环化及荧光turn-on原因. 另外, 本研究发现BNTP引入后分子表现出比参比分子Ph-BTTO4更优异的抗疲劳性、热稳定性和光稳定性, 尤其是在历经200 min 405 nm可见光照射后, BNTP-BTTO4(c)吸收强度只下降4%, 光稳定性大幅提升. 本研究为设计开发性能优异的可见光驱动光环化的荧光turn-on型二芳基乙烯提供了新的思路.     

Alkyl ketene dimer grafted cationic cellulose stabilizing nano magnesium oxide for efficient protection of acidic paper

Cellulose - Alkyl ketene dimer grafted cationic cellulose (AKD-g-CMCC) was designed to stabilize nano magnesium oxide (MgO) in low-polarity mixed solution of hexamethyldisiloxane (HMDSO) and...     

Zr基大块非晶合金的摩擦磨损性能

研究了以等电子浓度和等原子尺寸为依据设计的6种不同成分的非晶合金以及同非晶合金成分相同的4种晶态合金在干摩擦条件下同GCr15钢对摩时的摩擦磨损行为。结果表明：6种不同成分非晶合金的摩擦系数相近，均在0．5－0．6范围以内；4种晶态合金的摩擦系数均在0．4－0．5范围内，相同成分的晶态合金的摩擦系数比非晶合金的低，且显微硬度和耐磨性较高；非晶合金的磨损机制主要为塑性流变，晶态合金的磨损机制主要为脆性断裂以及磨粒磨损。     

Functional polymer/inorganic hybrid nanoparticles for macrophage targeting delivery of oligodeoxynucleotides in cancer immunotherapy

To efficiently deliver CpG oligodeoxynucleotides (ODN) in cancer immunotherapy, a multifunctional macrophage targeting delivery system was designed and prepared. Mannosylated carboxymethyl chitosan/protamine sulfate/CaCO₃/ODN (MCMC/PS/CaCO₃/ODN) nanoparticles were prepared using a facile self-assembly method. The functional components, including MCMC to endow the nanoparticles with macrophage targeting ability, PS to improve the ODN loading capacity and enhance the cell uptake, and CaCO₃ to encapsulate ODN and induce the favorable pH sensitivity, were introduced to the delivery systems by self-assembly. Due to the mannose mediated endocytosis and the favorable effects of PS in overcoming delivery barriers, MCMC/PS/CaCO₃/ODN nanoparticles exhibit a much higher ODN delivery efficiency and a significantly enhanced immune stimulation capacity as compared with Lipofectamine 2000/ODN complexes. The regulation of NF-κB activity by our ODN delivery system results in dramatically increased production of proinflammatory cytokines including IL-12, IL-6, and TNF-α in RAW264.7 cells. The significantly increased CD80 expression after stimulation by the ODN delivery systems indicates the successful modulation of the macrophage polarity to the anti-tumor M1 phenotype. The multifunctional macrophage targeting delivery system developed has promising applications in delivery of CpG ODN in cancer immunotherapy.     

2024铝合金在干摩擦往复运动条件下的磨损图研究

研究了 2 0 2 4铝合金 / 4 5 #钢摩擦副在干摩擦往复运动条件下的摩擦学特性 ,系统考察了载荷 98～ 4 90 N和速度0 .0 83～ 1.16 7m/ s范围内摩擦副材料的磨损行为 ;通过对磨损表面、断面以及铝在摩擦偶件的转移膜及磨屑的显微分析 ,建立了 2 0 2 4铝合金的磨损机制转变图 .结果表明 :2 0 2 4铝合金在低速和轻载条件下的磨损机制主要是磨粒磨损和剥层磨损 ;而在高速重载条件下的磨损机制主要是严重熔融磨损 ,并伴随向偶件材料表面的大量转移     

SYNTHESIS OF NICKEL NANOPOWDERS IN MICROEMULSION

IntroductionNanometer-scalecrystallitesofvariousmetalsandnonmetalshaveattractedagreatdealofattentionoverthepastdecade.Forsuchcrystallites,thephysicalandchemicalpropertiesareheavilydependentonparticlesizeandshape,and,asaresult,thesematerialshaveawiderangeofapplications(Ai&Kang,2003).Monodispersefinenickelparticlesarerequiredforhightechnologyapplicationsinalkalinerechargeablebatteries,magneticrecordingmediaandchemicalcatalysts,etc.,suchasconductingandmagneticinks,andferrofluids(Glicksman,1984).…     

基于粘度响应的线粒体靶向铱(Ⅲ)配合物用于肿瘤的光动力治疗

合成了2种含有转动基团的铱配合物Ir1和Ir2。研究发现Ir1和Ir2对粘度具有灵敏的荧光响应,在高粘度环境下,其荧光强度分别提高了35.7倍和1311.6倍。细胞摄取和共定位实验表明该探针能够轻易地穿过细胞膜并靶向聚集于线粒体中,对线粒体内粘度进行荧光成像检测。另外,通过EPR电子顺磁共振仪检测到Ir1和Ir2在光照下能够产生大量的单线态氧;同时发现配合物在肿瘤细胞中也能够产生高毒性的单线态氧,使Ir1和Ir2对A549细胞和Hep-G2细胞表现出很强的光毒性从而导致细胞死亡。     

Study on Synthesis of Silver Nanoparticles Using dsDNA as Template and Detection of GSH

In this work, silver nanoparticles are synthesized using a simple and sensitive method by using double-stranded DNA (dsDNA-Ag NPs) as a template. The prepared dsDNA-Ag NPs are characterized by fluorescence spectroscopy analysis, X-ray photoelectron spectroscopy analysis, and transmission electron microscopy analysis. The excitation wavelength of the prepared silver nanoparticles is 295 nm, the emission wavelength is 377 nm, the average particle size is 11.2 nm, and the dispersion is uniform with pleasurable stability. The nanomaterials are used as fluorescent probes to detect glutathione (GSH). After adding glutathione to the dsDNA-Ag NPs fluorescent probes, the fluorescence of dsDNA-Ag NPs is burst due to electron transfer and S Ag bond generation, and the linear range of detection concentration is 0–90 mm with a detection limit of 0.37 mm .     

Substituent effects on the photophysical properties of 2,9-substituted phenanthroline copper(I) complexes: a theoretical investigation

The electronic and nuclear structures of a series of [Cu(2,9-(X)₂-phen)₂]⁺ copper(I) complexes (phen=1,10-phenanthroline; X=H, F, Cl, Br, I, Me, CN) in their ground and excited states are investigated by means of density functional theory (DFT) and time-dependent (TD-DFT) methods. Subsequent Born-Oppenheimer molecular dynamics is used for exploring the T₁ potential energy surface (PES). The T₁ and S₁ energy profiles, which connect the degenerate minima induced by ligand flattening and Cu−N bond symmetry breaking when exciting the molecule are calculated as well as transition state (TS) structures and related energy barriers. Three nuclear motions drive the photophysics, namely the coordination sphere asymmetric breathing, the well-documented pseudo Jahn-Teller (PJT) distortion and the bending of the phen ligands. This theoretical study reveals the limit of the static picture based on potential energy surfaces minima and transition states for interpreting the luminescent and TADF properties of this class of molecules. Whereas minor asymmetric Cu−N bonds breathing accompanies the metal-to-ligand-charge-transfer re-localization over one or the other phen ligand, the three nuclear movements participate to the flattening of the electronically excited complexes. This leads to negligible energy barriers whatever the ligand X for the first process and significant ligand dependent energy barriers for the formation of the flattened conformers. Born-Oppenheimer (BO) dynamics simulation of the structural evolution on the T₁ PES over 11 ps at 300 K confirms the fast backwards and forwards motion of the phenanthroline within 200–300 fs period and corroborates the presence of metastable C₂ structures.